[HTML][HTML] Magnesium Isoglycyrrhizinate Reduces the Target-Binding Amount of Cisplatin to Mitochondrial DNA and Renal Injury through SIRT3
X Wang, H Zhu, J Hu, H Li, S Guo, B Chen… - International Journal of …, 2022 - mdpi.com
… , cisplatin-DNA binding levels in liver and brain mitochondrial … lack of nucleotide excision
repair pathways in mitochondria, … decreases platinum–mtDNA adducts to protect renal tubular …
repair pathways in mitochondria, … decreases platinum–mtDNA adducts to protect renal tubular …
[HTML][HTML] Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links
EO Boldinova, AV Yudkina, ES Shilkin… - Scientific reports, 2021 - nature.com
… of cisplatin–DNA adducts and their poor removal were reported for mitochondrial DNA as
compared to nuclear DNA … In this work, PrimPol preferentially incorporated two complementary …
compared to nuclear DNA … In this work, PrimPol preferentially incorporated two complementary …
Beyond base excision repair: an evolving picture of mitochondrial DNA repair
K Allkanjari, RA Baldock - Bioscience Reports, 2021 - portlandpress.com
… , mtDNA loss or a decrease in the number of functional copies of the mitochondrial genome
… of POLβ versus POLγ in gap filling correlates with preference for either short-patch or long-…
… of POLβ versus POLγ in gap filling correlates with preference for either short-patch or long-…
[HTML][HTML] Revisiting the anti-cancer toxicity of clinically approved platinating derivatives
BN Forgie, R Prakash, CM Telleria - International Journal of Molecular …, 2022 - mdpi.com
… not due to preferential repair of transplatin lesions by nucleotide … for forming mitochondrial
DNA (mtDNA) adducts than nDNA … Furthermore, in Chinese hamster ovary cells, there is not …
DNA (mtDNA) adducts than nDNA … Furthermore, in Chinese hamster ovary cells, there is not …
Unexpected therapeutic effects of cisplatin
… to be independent of cisplatin–DNA adduct formation. Indeed, … amount of adducts in
mitochondrial DNA (mtDNA), because … and Chinese hamster ovary cells. TREK-1 overexpression …
mitochondrial DNA (mtDNA), because … and Chinese hamster ovary cells. TREK-1 overexpression …
Mitochondria participate in chemoresistance to cisplatin in human ovarian cancer cells
LX Zampieri, D Grasso, C Bouzin, D Brusa… - Molecular Cancer …, 2020 - AACR
… Cisplatin–DNA adducts were quantified using the rat mAb CP9… E, Mitochondrial DNA content
normalized by nuclear DNA … ovarian cancer cell, preferentially cisplatin-resistant cells. Our …
normalized by nuclear DNA … ovarian cancer cell, preferentially cisplatin-resistant cells. Our …
Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy
PB Tchounwou, S Dasari, FK Noubissi… - Journal of …, 2021 - Taylor & Francis
… Citation10 The most common cisplatin-DNA adduct formation … The preference of cisplatin’s
affinity towards guanine at the N7… Cisplatin binds to mitochondrial DNA as well leading to cell …
affinity towards guanine at the N7… Cisplatin binds to mitochondrial DNA as well leading to cell …
[HTML][HTML] Cisplatin resistance in ovarian cancer: Classical outlook and newer perspectives
… due to larger N7 guanine content of the mitochondrial DNA. … Cisplatin based combination
chemotherapy is preferred in … further reduction of cisplatin-DNA adducts formation. Reduction in …
chemotherapy is preferred in … further reduction of cisplatin-DNA adducts formation. Reduction in …
Cisplatin in the era of PARP inhibitors and immunotherapy
… both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) … Studies in Chinese hamster
ovary cells showed that cisplatin … indicates that formation of a cisplatin-DNA adduct (intra- or …
ovary cells showed that cisplatin … indicates that formation of a cisplatin-DNA adduct (intra- or …
[HTML][HTML] Genome-wide adductomics analysis reveals heterogeneity in the induction and loss of cyclobutane thymine dimers across both the nuclear and mitochondrial …
AS Alhegaili, Y Ji, N Sylvius, MJ Blades… - International journal of …, 2019 - mdpi.com
… , we therefore simultaneously evaluated mitochondrial DNA … the mitochondrial genome, with
some loci targeted preferentially. … process for the removal of T<>T from mitochondrial DNA. …
some loci targeted preferentially. … process for the removal of T<>T from mitochondrial DNA. …